Hypothyroidism induced by antituberculosis drugs

Tuberculosis is an infectious disease that affects practically all organs, including the thyroid gland. In same time, hypofunction of gland may increase susceptibility to infection with Mycobacterium tuberculosis. Antituberculosis treatment, especially second-line drugs, can lead hypothyroidism. It has been found rifampicin, ethionamide, prothionamide and para-aminosalicylic acid are among most common antituberculosis drugs responsible for development These preparations/agents cause dysfunction by increasing metabolism clearance hormones inducing cytochrome P-450 enzymes, deregulating/ iodine uptake synthesis hormones, altering hormone receptor action intracellular signal transduction. The treatment these medications requires monitoring function during in first 3 months, but also post-treatment period. installation clinical and/or subclinical hypothyroidism will require use appropriate doses levothyroxine treatment.